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A new convenient transformation of erythromycin A into clarithromycin
P Allevi1, A Longo, M Anastasia
1Dipartimento di Chimica e Biochimica Medica, University of Milan, Italy. pietro.allevi@unimi.it
Bioorganic & Medicinal Chemistry
|February 5, 2000
Abstract:
Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4''-hydroxy groups, methylation of the resulting 2',4''-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.