[Polymorphonuclear rosettes in the peripheral blood of multiple sclerosis patients]

The study is related to the distribution of rossette-forming cells--lymphocytic and polymorphonuclear leukocytic--lymphocytes and polymorphonuclear leukocytes (neutrophils) in the peripheral blood of patients with disseminated sclerosis. An increase of the polymorphonuclear leukocytes and polymorphonuclear leukocytic content was found in the exacerbation period. Similar data were obtained in the process of reproduction of chronic experimental allergic encephalitis in maccaca rhesus. Moreover, in a rapid development of the disease polymorphonuclear leukocytic cells in the patients did not differ from the control group. The established distribution of lymphocytes and polymorphonuclear leukocytes and polymorphonuclear leukocytic cells correlated with the accelerated maturation of leukocytes in the neutrophil range in the bone marrow. The possible role of polymorphonuclear leukocytes in the pathogenesis of disseminated sclerosis is discussed.