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Updated: Jul 22, 2026

A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
Published on: March 21, 2014
Expression of the mucosal vascular addressin, MAdCAM-1, in inflammatory liver disease
K J Hillan1, K E Hagler, R N MacSween
1Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
Aims/Background:
The integrin alpha4beta7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are involved in normal recirculation of lymphocytes between the blood and the tissues of the gastrointestinal tract. In this study we have examined the expression of MAdCAM-1 in human liver.
Methods:
MAdCAM-1 expression was determined in archival human liver tissues by immunohistochemistry.
Results:
While MAdCAM-1 was not detected in normal fetal or adult human liver, expression was observed in association with portal tract inflammation in a variety of liver diseases. Detailed analysis of liver biopsies from patients with hepatitis C showed a positive correlation between the portal/periportal component of the histological activity index (HAI) grade and the presence or absence of MAdCAM-1 expression.
Conclusion:
MAdCAM-1 expression may be important in the recruitment of lymphocytes to the liver during inflammation.
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