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Updated: Aug 13, 2026

Generation of RNA/DNA Hybrids in Genomic DNA by Transformation using RNA-containing Oligonucleotides
Published on: November 24, 2010
The importance of being r: greater oxidative stability of RNA compared with DNA
1Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA. holden@unc.edu
Abstract:
The 2'-hydroxyl group of ribose imparts hydrolytic lability on RNA, which provides a mechanism for numerous biological functions. Recent evidence from chemical cleavage studies shows that this hydroxyl group also stabilizes the sugar moiety in RNA towards oxidation relative to DNA. Is this just because RNA needs to be distinguishable from DNA or does it have other evolutionary significance?
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