Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

Cellular Adaptation III: Hyperplasia

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

Cirrhosis II: Pathophysiology

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Characteristic histopathology of phenprocoumon-induced liver injury: correlation with clinical presentation and outcome.

Virchows Archiv : an international journal of pathology·2026

Same author

Grapevine adopts different strategies in response to drying regimes. Procrastinator or escaper?

Journal of plant physiology·2025

Same author

Comparison of Data-Dependent Acquisition, Data-Independent Acquisition, and Parallel Reaction Monitoring in Trapped Ion Mobility Spectrometry-Time-of-Flight Tandem Mass Spectrometry-Based Lipidomics.

Analytical chemistry·2023

Same author

Usage of C-Reactive Protein Testing in the Diagnosis and Monitoring of Psoriatic Arthritis (PsA): Results from a Real-World Survey in the USA and Europe.

Rheumatology and therapy·2022

Same author

Two-color Kerr microscopy of two-dimensional materials with sub-picosecond time resolution.

The Review of scientific instruments·2021

Same author

Repeated exposure of the oral mucosa over 12 months with cold plasma is not carcinogenic in mice.

Scientific reports·2021

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

Nodular regenerative hyperplasia of the liver: case report of a 13-year-old girl and review of the literature.

G M Trenschel¹, A Schubert, V Dries

¹Department of Diagnostic Radiology, Paediatric Radiology, University of Cologne Medical School, Kerpener Strasse 68, D-50924 Cologne, Germany.

Pediatric Radiology

|February 9, 2000

Summary

Nodular regenerative hyperplasia (NRH) is a rare liver condition. Early diagnosis via biopsy is crucial for good prognosis, especially when portal hypertension is absent.

More Related Videos

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Published on: March 27, 2026

Related Experiment Videos

Last Updated: Jul 8, 2026

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Published on: March 27, 2026

Area of Science:

Hepatology
Pediatric Gastroenterology

Background:

Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by multiple regenerative nodules in a non-cirrhotic liver.
Its etiology is often unknown, particularly in pediatric cases.

Observation:

NRH is frequently associated with other medical conditions or drug use.
Hepatomegaly and multiple large nodules were observed in this case.

Findings:

Radiological imaging of NRH can mimic neoplastic lesions.
Portal hypertension complicates approximately half of NRH cases.

Implications:

Open wedge biopsy is essential for accurate NRH diagnosis.
Prognosis for NRH without portal hypertension is generally favorable.
Complications like nodule rupture are infrequent.