Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Post-irradiation sudden deafness.

Y H Young1, P J Lou

  • 1Department of Otolaryngology, National Taiwan University, Taipei, Taiwan. youngyh@ha.mc.ntu.edu.tw

The Journal of Laryngology and Otology
|February 9, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Final results of a randomized phase III trial of induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in patients with stage IVA and IVB nasopharyngeal carcinoma-Taiwan Cooperative Oncology Group (TCOG) 1303 Study.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

Production of thuringiensin from Bacillus thuringiensis using a net-draft-tube, modified airlift reactor.

World journal of microbiology & biotechnology·2014
Same author

Consensus recommendations for management of head and neck cancer in Asian countries: a review of international guidelines.

Oral oncology·2013
Same author

Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families.

British journal of cancer·2011
Same author

The effects of power on-off durations of pulsed ultrasound on the destruction of cancer cells.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2007
Same author

Toxic effects of potassium bromate and thioglycolate on vestibuloocular reflex systems of Guinea pigs and humans.

Toxicology and applied pharmacology·2001
Same journal

Discomfort and Intolerance During 24-Hour Multichannel Intraluminal Impedance-pH Monitoring.

The Journal of laryngology and otology·2026
Same journal

The Effect of Hand Dominance on Results in the Functional Head Impulse Test.

The Journal of laryngology and otology·2026
Same journal

Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis.

The Journal of laryngology and otology·2026
Same journal

Surgical Management Of Parapharyngeal Vagal Schwannomas: A Systematic Review And Practical Considerations For Approach Selection.

The Journal of laryngology and otology·2026
Same journal

Novel Use of Lieberman Self-Retainers for Nasal Alar Retraction.

The Journal of laryngology and otology·2026
Same journal

Prevalence and recovery of taste dysfunction after stapedectomy in otosclerosis: a clinical study of 320 patients.

The Journal of laryngology and otology·2026
See all related articles

Post-irradiation sudden deafness (PISD) is a late complication in nasopharyngeal carcinoma (NPC) patients, occurring years after radiation therapy. While severe, 60% of patients experienced hearing recovery after treatment, suggesting vascular insufficiency as a potential cause.

Area of Science:

  • Otolaryngology
  • Radiation Oncology
  • Oncology

Background:

  • Post-irradiation sudden deafness (PISD) is a recognized complication following radiation therapy.
  • Nasopharyngeal carcinoma (NPC) patients are susceptible to late-onset auditory dysfunction after radiotherapy.

Purpose of the Study:

  • To investigate the incidence, characteristics, and outcomes of PISD in NPC patients.
  • To explore potential causative mechanisms for PISD in this cohort.

Main Methods:

  • Retrospective analysis of 15 nasopharyngeal carcinoma patients diagnosed with PISD.
  • Evaluation of the time interval between irradiation completion and PISD onset.
  • Assessment of hearing loss severity and treatment response.

Main Results:

Related Experiment Videos

  • PISD occurred a mean of 12 years post-irradiation.
  • The cohort presented with varying degrees of hearing loss, including total deafness and profound/moderate hearing impairment.
  • Sixty percent (9/15) of patients achieved hearing recovery within three months of treatment initiation.

Conclusions:

  • PISD is a significant late-onset complication in NPC patients treated with radiation.
  • Vascular insufficiency is hypothesized as the primary underlying mechanism for PISD.
  • Prompt treatment may lead to favorable hearing recovery in a majority of affected patients.