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Inhibition of aflatoxin biosynthesis by phenolic compounds
S S Hua1, O K Grosjean, J L Baker
1U.S. Department of Agriculture, Western Regional Research Center, Albany, C.A. 94710, USA.
Letters in Applied Microbiology
|February 9, 2000
Abstract:
The phenolic compounds acetosyringone, syringaldehyde and sinapinic acid inhibited the biosynthesis of aflatoxin B1 (AFB1) by A. flavus. Acetosyringone was the most active among the three compounds, inhibiting aflatoxin level by 82% at 2 m moll-1. The synthesis and accumulation of norsolorinic acid, an aflatoxin biosynthetic intermediate, was also inhibited. These results suggest that at least one step early in the AFB1 biosynthetic pathway is inhibited by the phenolics.