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Related Experiment Videos

5-fluorouracil-induced erythema multiforme.

S K Lo1, D Yip, M Leslie

  • 1Department of Medical Oncology, Guy's Hospital, London, UK.

International Journal of Clinical Practice
|February 9, 2000
PubMed
Summary
This summary is machine-generated.

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Erythema multiforme is a skin reaction that can be triggered by chemotherapy. This report details two cases where 5-fluorouracil (5-FU) caused this reaction, which resolved upon drug discontinuation.

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Erythema multiforme (EM) is an immune-mediated skin reaction to foreign antigens, often drug-induced.
  • The association between 5-fluorouracil (5-FU), a common chemotherapy agent, and EM has not been previously documented.

Purpose of the Study:

  • To report the first two cases of erythema multiforme induced by 5-fluorouracil (5-FU) chemotherapy.
  • To describe the clinical presentation, histological findings, and treatment response in patients developing 5-FU-induced EM.

Main Methods:

  • Case report detailing two patients with advanced cancers receiving 5-FU chemotherapy.
  • Clinical observation of skin lesions, including rash, mouth ulceration, and plantar-palmar erythrodysaesthesia.
  • Histological examination of skin biopsy specimens.

Related Experiment Videos

  • Assessment of lesion response to 5-FU treatment and alternative therapies (raltitrexed).

    • Main Results:

    • Two patients developed classic erythema multiforme, including mucocutaneous lesions and palmar-plantar changes, during 5-FU treatment for gastric and colon cancer.
    • Skin lesions resolved spontaneously upon 5-FU discontinuation and recurred upon re-challenge.
    • One patient experienced complete resolution of EM symptoms after switching to raltitrexed, a thymidylate synthase inhibitor.

    Conclusions:

    • 5-fluorouracil (5-FU) can induce erythema multiforme as a distinct adverse drug reaction.
    • Recurrence of EM upon 5-FU re-administration confirms the drug's causative role.
    • Alternative chemotherapy, such as raltitrexed, may be a viable option for patients experiencing 5-FU-induced EM.