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The neuropsychiatry of stroke

E Chemerinski1, R G Robinson

  • 1Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA. eranchemerinski@uiowa.edu

Psychosomatics
|February 9, 2000
PubMed

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...