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[Interferon status of patients with uveal melanoma]
Interferon status of patients with uveal melanoma was studied at different stages of the disease. All parameters of alpha- and gamma-interferon production were decreased both in vitro and in vivo. The T2-3 stages were associated with an imbalance of the production of two interferon types: augmenting deficiency of alpha-interferon with a tendency to a higher production of gamma-interferon by leukocytes in vitro. Generalization of T3-4N0Mhep melanoma was characterized by hyperproduction of gamma-interferon and total serum interferon. These data indicate a pathogenetic significance of disorders in interferon production in uveal melanoma and may be used for the disease prognosis.
Interferon status of patients with uveal melanoma was studied at different stages of the disease. All parameters of alpha- and gamma-interferon production were decreased both in vitro and in vivo. The T2-3 stages were associated with an imbalance of the production of two interferon types: augmenting deficiency of alpha-interferon with a tendency to a higher production of gamma-interferon by leukocytes in vitro. Generalization of T3-4N0Mhep melanoma was characterized by hyperproduction of gamma-interferon and total serum interferon. These data indicate a pathogenetic significance of disorders in interferon production in uveal melanoma and may be used for the disease prognosis.