Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rh gene evolution in primates: study of intron sequences.

P A Apoil1, A Blancher

  • 1Laboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Hôpital Purpan, Toulouse, France.

Molecular Biology and Evolution
|February 10, 2000
PubMed
Summary

An Alu-Sx element insertion in the RH gene ancestor of primates occurred millions of years ago. This ancient insertion and subsequent gene duplications and exchanges shaped RH gene diversity in humans, apes, and monkeys.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutaneous mastocytosis in adults with a serum tryptase level < 20 ng mL<sup>-1</sup> : why we should investigate further.

The British journal of dermatology·2021
Same author

Frequency of isolated cutaneous involvement in adult mastocytosis: a cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Higher prevalence of vertebral fractures in systemic mastocytosis, but not in cutaneous mastocytosis and idiopathic mast cell activation syndrome.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Effect of dupilumab on atopic manifestations in patients treated for atopic dermatitis in real-life practice.

The British journal of dermatology·2019
Same author

A clinical and neurophysiological motor signature of Unverricht-Lundborg disease.

Revue neurologique·2017
Same author

Reference values for T, B and NK human lymphocyte subpopulations in adults.

Data in brief·2017

Area of Science:

  • Genetics
  • Primate Evolution
  • Molecular Biology

Background:

  • The RH gene is crucial for blood group determination.
  • Understanding RH gene evolution provides insights into primate genetic history.
  • Previous studies have identified variations in RH gene introns across species.

Purpose of the Study:

  • To investigate the evolutionary history of the RH gene in primates.
  • To identify the origin and insertion point of the Alu-Sx element in RH intron 4.
  • To explore gene duplication and exchange events in RH genes of humans, apes, and monkeys.

Main Methods:

  • Amplification and sequencing of RH gene introns 3 and 4 from various primate species.
  • Comparative analysis of intron sequences to identify insertions, deletions, and length polymorphisms.

Related Experiment Videos

  • Phylogenetic analysis to determine the evolutionary relationships and insertion timing of genetic elements.

    • Main Results:

    • An Alu-Sx-like element was inserted in the RH gene of the common ancestor of all studied primates.
    • RH gene duplication in the common ancestor of humans, chimpanzees, and gorillas led to genes with and without the Alu-Sx element.
    • Chimpanzees and gorillas exhibit distinct RH intron 3 and 4 associations, indicating intergenic exchanges similar to humans.

    Conclusions:

    • The Alu-Sx element insertion predates the divergence of major primate groups.
    • Gene duplication and intergenic exchanges have played significant roles in shaping RH gene evolution across primates.
    • Comparative analysis of RH gene introns reveals conserved and divergent evolutionary pathways in primates.