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[Prognosis factors in cryptococcal meningoencephalitis].

C Darzé1, R Lucena, I Gomes

  • 1Divisão de Neuroinfectologia e Neuroepidemiologia Universidade Federal da Bahia (UFBA), Brasil.

Arquivos De Neuro-Psiquiatria
|February 10, 2000
PubMed
Summary

Cryptococcal meningoencephalitis lethality was 42.7%. Longer disease duration, impaired consciousness, and low cerebrospinal fluid (CSF) cell counts predicted higher mortality in this infectious disease study.

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Area of Science:

  • Infectious Diseases
  • Neurology
  • Epidemiology

Background:

  • Cryptococcal meningoencephalitis is a serious fungal infection of the brain and meninges.
  • Intrahospitalar lethality remains a significant concern in managing this condition.

Purpose of the Study:

  • To identify demographic, clinical, and cerebrospinal fluid (CSF) variables associated with intrahospitalar lethality in patients diagnosed with cryptococcal meningoencephalitis.

Main Methods:

  • Retrospective cohort study design.
  • Data collected from patients admitted to Hospital Couto Maia (HCMaia), a reference center for infectious diseases in Bahia, Brazil, between 1972 and 1996.

Main Results:

  • The overall lethality rate was 42.7%.

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  • Neurological abnormalities included neck stiffness, decreased consciousness, behavioral changes, cranial nerve palsy, and visual alterations.
  • Disease duration exceeding 30 days, impaired consciousness, and CSF cell counts below 40/mm³ were associated with increased lethality.

    • Conclusions:

    • Disease duration over 30 days, altered consciousness level, and decreased CSF cellularity were identified as the sole predictors of lethality.
    • These findings highlight critical factors for prognosis assessment in cryptococcal meningoencephalitis.