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Related Concept Videos

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
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Central to the gray matter is...

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Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
12:17

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Published on: January 19, 2012

Nodal signalling in vertebrate development.

A F Schier1, M M Shen

  • 1Department of Cell Biology, New York University School of Medicine, New York 10016, USA. schier@saturn.med.nyu.edu

Nature
|February 10, 2000
PubMed
Summary
This summary is machine-generated.

Cellular communication via the Nodal signaling pathway is crucial for establishing the vertebrate body plan during early embryogenesis. This pathway regulates key developmental events, including axis formation and tissue patterning.

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Area of Science:

  • Developmental biology
  • Cell signaling
  • Molecular biology

Background:

  • Cellular communication is fundamental for vertebrate embryogenesis and body plan organization.
  • The Nodal signaling pathway, a member of the transforming growth factor beta superfamily, plays a central role in embryonic development.

Purpose of the Study:

  • To elucidate the role of the Nodal signaling pathway in vertebrate embryogenesis.
  • To understand how Nodal signaling regulates mesoderm and endoderm formation, axis specification, and neural patterning.

Main Methods:

  • Investigated the Nodal signaling pathway and its regulators.
  • Focused on the extracellular regulation by EGF-CFC cofactors and Lefty/Cerberus antagonists.

Main Results:

  • Nodal signaling is essential for configuring the vertebrate embryo.
  • Extracellular regulators precisely control Nodal activity.
  • Nodal pathway activity influences mesoderm/endoderm formation, anterior-posterior axis, neural patterning, and left-right axis specification.

Conclusions:

  • The Nodal signaling pathway is a key regulator of early vertebrate development.
  • Extracellular modulation of Nodal activity by specific protein families ensures accurate embryonic patterning.