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Small bowel transplantation.

N S Hakim1, V E Papalois

  • 1Transplant Unit, St Mary's Hospital, London, UK.

International Surgery
|February 10, 2000
PubMed
Summary
This summary is machine-generated.

Many patients require a functional small bowel for survival, but intestinal failure affects 2-3 per million annually. Small bowel transplantation is a potential option for those with irreversible failure on long-term total parenteral nutrition (TPN).

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Area of Science:

  • Gastroenterology
  • Transplantation Surgery
  • Clinical Medicine

Background:

  • Small intestinal absorptive surface is crucial for survival, with individual requirements varying.
  • Prolonged survival with limited jejunum (15-45 cm) and intact duodenum is possible but rare.
  • Long-term total parenteral nutrition (TPN) is often necessary but carries significant complications.

Purpose of the Study:

  • To estimate the incidence of irreversible small bowel failure.
  • To identify potential candidates for small bowel transplantation.

Main Methods:

  • Analysis of data from patients on long-term TPN.
  • Epidemiological estimation of small bowel failure incidence.
  • Assessment of UK home TPN recipients as transplant candidates.

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Main Results:

  • Irreversible small bowel failure affects an estimated 2-3 individuals per million population annually.
  • Approximately 20 new UK patients receiving home TPN annually may be candidates for small bowel transplantation.

Conclusions:

  • Small bowel failure is a rare but serious condition necessitating TPN.
  • Small bowel transplantation represents a viable therapeutic option for select patients with irreversible intestinal failure.