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Normal values for arsenic and selenium concentrations in human lung tissue.

T Kraus1, G Quidenus, K H Schaller

  • 1Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine of the University of Erlangen-Nuremberg, Schillerstrasse 25 and 29, D-91054 Erlangen, Germany.

Archives of Environmental Contamination and Toxicology
|February 10, 2000
PubMed
Summary

Normal arsenic and selenium levels in human lung tissue show high variation. Postmortem analysis of these elements in lung tissue can reveal past environmental or occupational exposures.

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Area of Science:

  • Toxicology
  • Environmental Health
  • Pathology

Background:

  • Arsenic and selenium are trace elements with potential health implications.
  • Understanding normal concentration ranges in human tissues is crucial for assessing exposure.
  • Lung and hilar lymph node tissues are potential sites for element accumulation.

Purpose of the Study:

  • To establish normal concentration ranges for arsenic and selenium in human lung and hilus tissue.
  • To investigate the factors influencing these concentrations, including age, smoking, and disease.
  • To evaluate the utility of postmortem tissue analysis for assessing exposure.

Main Methods:

  • Autopsy samples from 50 deceased individuals were analyzed.
  • Hydride atomic absorption spectrometry was used after wet-oxidative digestion.

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  • Samples included lung lobes and hilar lymph nodes, with attention to topographic-anatomical criteria.

    • Main Results:

    • Normal arsenic range: <1-74 ng/g dry weight; Selenium range: <3-574 ng/g dry weight.
    • Arsenic accumulated in hilus tissue; selenium did not.
    • High intraindividual and interindividual variation observed for both elements; no significant differences based on age, smoking, or lung disease.

    Conclusions:

    • Wide normal ranges are necessary due to high arsenic and selenium variability in lung tissue.
    • Age, smoking, and lung diseases did not significantly alter these ranges.
    • Postmortem lung tissue analysis is valuable for determining past occupational or environmental exposure to arsenic and selenium.