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Synthesis of various analog derivatives of ORG13514 as 5-HT1A ligands
1Institut de Chimie Organique et Analytique, associé CNRS, Université d'Orléans, France. c.comoy@meseb.u-nancy.fr
Farmaco (Societa Chimica Italiana : 1989)
|February 11, 2000
Abstract:
In connection with the development of new potential 5-HT1A ligands, multistep synthesis of N-substituted-3-aminomethyl-2,3-dihydro-1,4-dioxinol[2,3-b]pyridin e derivatives as ORG13514 analogs are described. Their biological activity as 5-HT1A type ligands is reported and compared with ORG13514 affinity and selectivity for 5-HT1A receptors.