Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin receptors and ligands.

P A Witt-Enderby1, P K Li

  • 1Department of Pharmacology and Toxicology, Graduate School of the Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

Vitamins and Hormones
|February 11, 2000
PubMed
Summary

This review explores melatonin receptor interactions and ligands, aiming to develop crucial clinical tools. Understanding these interactions enhances knowledge of melatonin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice.

European journal of obstetrics, gynecology, and reproductive biology·2013
Same author

Kala-Azar in Children of North China.

Archives of disease in childhood·2010
Same author

The Treatment of Kala Azar in Children.

Archives of disease in childhood·2010
Same author

Asymptomatic isolated microscopic haematuria: long-term follow-up.

QJM : monthly journal of the Association of Physicians·2004
Same author

Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization.

Life sciences·2004
Same author

The cost barrier to peritoneal dialysis in the developing world--an Asian perspective.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2002

Area of Science:

  • Pharmacology
  • Neuroscience
  • Medicinal Chemistry

Background:

  • Melatonin receptors (MT1, MT2) are crucial for various physiological processes.
  • Current understanding of melatonergic ligands and their receptor affinities is fragmented.
  • Developing selective and high-affinity ligands is essential for therapeutic advancements.

Purpose of the Study:

  • To clarify the interactions between melatonin, its analogs, and melatonin receptors.
  • To compile existing melatonergic ligands and their receptor affinities.
  • To highlight the importance of developing novel melatonin receptor antagonists and ligands.

Main Methods:

  • Literature review of published melatonergic ligands and their properties.
  • Analysis of ligand affinities for different melatonin receptor subtypes.
  • Discussion of challenges in current receptor pharmacology models.

Main Results:

  • Compilation of known melatonergic ligands and their receptor binding data.
  • Identification of the need for reversible, high-affinity, and subtype-selective antagonists.
  • Exploration of the utility of high-affinity charged and irreversible melatonergic ligands.

Conclusions:

  • Advancements in melatonergic ligand design are critical for understanding melatonin receptor function.
  • Improved tools will deepen knowledge of melatonin receptor structure and physiological roles.
  • Further research on melatonergic ligands will elucidate melatonin's role in human health.

Related Experiment Videos