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Related Experiment Videos

Apoptosis: a two-edged sword in aging.

H R Warner1

  • 1Biology of Aging Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. warnerh@exmur.nia.nih.gov

Annals of the New York Academy of Sciences
|February 11, 2000
PubMed
Summary
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Apoptosis, or programmed cell death, has dual roles in aging. Understanding its positive and negative impacts is key to developing interventions targeting mitochondrial function and cell elimination for longevity.

Area of Science:

  • Gerontology and Cellular Biology
  • Molecular mechanisms of aging
  • Mammalian aging processes

Background:

  • Apoptosis (programmed cell death) plays a complex role in mammalian aging.
  • Previous reviews have highlighted the significance of apoptosis in aging.
  • Understanding both beneficial and detrimental effects is crucial for therapeutic development.

Purpose of the Study:

  • To summarize current knowledge on the positive and negative impacts of apoptosis in aging mammalian systems.
  • To provide an updated review of apoptosis's role in aging.
  • To identify potential therapeutic interventions based on apoptosis modulation.

Main Methods:

  • Literature review and synthesis of existing research on apoptosis and aging.
  • Analysis of physiological and molecular approaches for intervention.

Related Experiment Videos

  • Consideration of transgenic interventions.

    • Main Results:

    • Apoptosis has both beneficial and detrimental effects during aging.
    • Mitochondria are critical in reactive oxygen species generation and apoptosis initiation.
    • Maintaining mitochondrial function is a potential therapeutic goal, particularly in post-mitotic tissues.
    • Apoptosis-mediated elimination of damaged cells has anti-aging implications in mitotic tissues.

    Conclusions:

    • Modulating apoptosis offers therapeutic potential for aging.
    • Targeting mitochondrial function is a promising strategy for age-related interventions.
    • Leveraging apoptosis for cellular clearance in mitotic tissues may promote longevity.