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Related Experiment Videos

Engineering tissues and organs.

A Atala1

  • 1Department of Urology, Children's Hospital, Boston, Massachusetts, USA. Atala@a1.tch.harvard.edu

Current Opinion in Urology
|February 11, 2000
PubMed
Summary
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Tissue engineering enables the creation of functional genitourinary tissues and organs for reconstructive urology. This innovative approach holds promise for future urologic surgical applications.

Area of Science:

  • Regenerative Medicine
  • Urologic Engineering
  • Biomaterials Science

Background:

  • Genitourinary tissue reconstruction can be achieved through in-vitro and in-vivo tissue engineering.
  • This field integrates cell biology and materials science for functional tissue development.
  • Existing research has successfully engineered various urologic tissues, including bladder, kidney, and urethra, with demonstrated functionality.

Purpose of the Study:

  • To explore the application of tissue engineering in the development of functional genitourinary tissues and organs.
  • To highlight the interdisciplinary nature of tissue engineering, combining cell biology and materials science.
  • To review the current state and future potential of tissue engineering in reconstructive urology.

Main Methods:

Related Experiment Videos

  • Utilizing selective cell transplantation with acellular matrices for tissue regeneration.
  • Employing an interdisciplinary approach combining cell biology and materials science techniques.
  • Documenting the successful in-laboratory creation of various urologic tissues.

    • Main Results:

    • Engineered tissues and organs such as the bladder, kidney, testis, ureter, and urethra have been created with varying functionality.
    • Cells are being utilized as bulking agents for treating conditions like vesicoureteral reflux and urinary incontinence.
    • The study demonstrates the feasibility of laboratory-based genitourinary tissue creation.

    Conclusions:

    • Tissue engineering offers a promising avenue for genitourinary tissue and organ reconstruction.
    • The application of cell transplantation and biomaterials is advancing reconstructive urology.
    • Continued evolution of tissue engineering science is expected to expand its role in urologic surgery.