Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DHEA and the skeleton (through the ages).

C M Gordon1, J Glowacki, M S LeBoff

  • 1Division of Adolescent/Young Adult Medicine, Children's Hospital, Boston, MA 02115, USA. Gordon_c@al.tch.harvard.edu

Endocrine
|February 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

Forearm bone mineral density and fracture incidence in postmenopausal women with osteoporosis: results from the ACTIVExtend phase 3 trial.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

A case-control pilot study of stress fracture in adolescent girls: the discriminative ability of two imaging technologies to classify at-risk athletes.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.

Bone·2019
Same author

VITamin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018

Dehydroepiandrosterone (DHEA) influences bone health by affecting growth factors and cytokines. This review explores DHEA

Area of Science:

  • Endocrinology
  • Bone Physiology
  • Steroid Biochemistry

Background:

  • Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are abundant human steroids with incompletely understood functions.
  • Circulating DHEA(S) levels exhibit distinct patterns throughout life, peaking in young adulthood and declining significantly with age.
  • The role of DHEA in skeletal physiology is an area of ongoing research.

Purpose of the Study:

  • To review the role of DHEA in skeletal physiology.
  • To examine DHEA's modulation of skeletal insulin-like growth factor (IGF) regulatory systems.
  • To discuss DHEA's effects on proresorptive cytokine secretion and its potential therapeutic applications in bone diseases.

Main Methods:

  • Literature review of studies on DHEA and skeletal health.

Related Experiment Videos

  • Analysis of DHEA secretion patterns across the human lifespan.
  • Evaluation of DHEA's impact on bone metabolism and related signaling pathways.

    • Main Results:

    • DHEA influences the skeletal IGF system.
    • DHEA affects the secretion of cytokines involved in bone resorption.
    • Age-related decline in DHEA levels correlates with bone changes.

    Conclusions:

    • DHEA plays a significant role in maintaining bone health.
    • DHEA exhibits anabolic and anti-resorptive effects on bone.
    • Further research into DHEA's therapeutic potential for bone diseases is warranted.