Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholinergic dysfunction in diseases with Lewy bodies.

P Tiraboschi1, L A Hansen, M Alford

  • 1Neurologia Prima, Ospediali Riuniti, Bergamo, Italy.

Neurology
|February 11, 2000
PubMed
Summary

Cholinergic dysfunction is significant in Lewy body diseases, independent of Alzheimer's disease pathology. Midfrontal cholinergic deficits may distinguish Lewy body variant of Alzheimer's disease from Alzheimer's disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in demographics and clinical outcomes in older, middle-aged, and younger adults with low back pain receiving chiropractic care.

Chiropractic & manual therapies·2025
Same author

Corrigendum to "Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease" [Neuroscience 202 (2012) 405-412].

Neuroscience·2025
Same author

Corrigendum to "Silencing of murine transthyretin and retinol binding protein genes have distinct and shared behavioral and neuropathologic effects" [Neuroscience 275 (2014) 352-364].

Neuroscience·2025
Same author

Corrigendum to "Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice" [Neuroscience 169(1) (2010) 488-494].

Neuroscience·2025
Same author

Inversion Recovery Ultrashort TE MR Imaging of Myelin is Significantly Correlated with Disability in Patients with Multiple Sclerosis.

AJNR. American journal of neuroradiology·2021
Same author

Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.

BMC neuroscience·2017

Area of Science:

  • Neuroscience
  • Neuropathology
  • Neurochemistry

Background:

  • Diseases with Lewy bodies (LB), including LB variant of Alzheimer's disease (LBV), diffuse LB disease (DLBD), and Parkinson's disease (PD), exhibit decreased choline acetyltransferase (ChAT) activity, similar to Alzheimer's disease (AD).
  • APOE epsilon4 allele frequency is elevated in LBV, but its impact on cholinergic function remains unclear.

Purpose of the Study:

  • To evaluate cholinergic activity in LB diseases (LBV, DLBD, PD) compared to AD and normal controls (NC).
  • To determine if AD pathology is necessary for cholinergic dysfunction.
  • To assess if cholinergic decline differs between neocortical and archicortical areas.
  • To investigate the influence of APOE genotype on cholinergic loss.

Main Methods:

Related Experiment Videos

  • Analysis of an autopsy series including 182 AD, 49 LBV, 11 PD, 6 DLBD, and 16 NC subjects.
  • Determination of APOE genotype and ChAT activity in midfrontal and hippocampal cortices.

    • Main Results:

    • Marked reduction in midfrontal ChAT activity in LB diseases (LBV, PD, DLBD) compared to NC and AD (p < 0.001 and p < 0.05, respectively).
    • Midfrontal ChAT activity decline was similar in LBV, DLBD, and PD, irrespective of AD pathology.
    • LBV showed a greater midfrontal cholinergic deficit compared to AD, while hippocampal ChAT activity was similar between LBV and AD, but reduced in both compared to NC (p < 0.001).
    • APOE epsilon4 allele dosage did not affect midfrontal ChAT activity in LBV.

    Conclusions:

    • Significant midfrontal cholinergic deficits occur in LB diseases, independent of AD.
    • A more pronounced midfrontal cholinergic deficit may differentiate LBV from AD.
    • Other factors, not APOE genotype, likely contribute to cholinergic decline in LBV.