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Hypercoagulable states in primary upper-extremity deep vein thrombosis.
E Héron1, O Lozinguez, M Alhenc-Gelas
1Service de Médecine Vasculaire and Centre Claude Bernard de Recherche sur les Maladies Vasculaires Périphériques, Paris, France.
Archives of Internal Medicine
|February 11, 2000
Summary
Coagulation abnormalities are linked to idiopathic upper-extremity deep vein thrombosis (UEDVT), but not effort-related UEDVT. This suggests hypercoagulable states are key factors in non-effort UEDVT cases.
Area of Science:
- Hematology
- Vascular Medicine
- Thrombosis Research
Background:
- Limited data exist on coagulation abnormalities in upper-extremity deep vein thrombosis (UEDVT).
- Understanding these abnormalities is crucial for diagnosing and managing UEDVT.
- Prevalence studies are needed to clarify risk factors.
Purpose of the Study:
- To investigate the role of coagulation abnormalities in effort-related and idiopathic UEDVT.
- To compare the prevalence of clotting disorders between different UEDVT subtypes.
- To identify potential risk factors for UEDVT development.
Main Methods:
- Screening of plasma for antithrombin, protein C, and protein S deficiencies.
- Testing for antiphospholipid antibodies, including lupus anticoagulant and anticardiolipin antibodies.
- Genetic screening for factor V Leiden and prothrombin gene G20210A mutations in 51 UEDVT patients.
Main Results:
- Idiopathic UEDVT patients were older, more frequently women, and had higher rates of personal/family history of thromboembolism compared to effort-related UEDVT.
- A higher proportion of patients with idiopathic UEDVT (42%) had at least one coagulation abnormality versus effort-related UEDVT (15%).
- The odds of having a coagulation abnormality were significantly higher in the idiopathic UEDVT group (OR=4.09).
Conclusions:
- Hypercoagulable states significantly contribute to the development of idiopathic UEDVT.
- Coagulation abnormalities do not appear to play a major role in effort-related UEDVT.
- Findings highlight the importance of screening for clotting disorders in patients with non-effort UEDVT.