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Leukocyte recruitment and the acute inflammatory response
1Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Alberta, Canada. pkubes@ucalgary.ca
Brain Pathology (Zurich, Switzerland)
|February 11, 2000
Summary
Leukocyte recruitment, a key part of inflammation, involves cell rolling and adhesion. This review details these processes and explores how the inflammatory response is regulated, particularly concerning Nf kappaB signaling.
Area of Science:
- Immunology
- Cell Biology
- Neuroscience
Background:
- Leukocyte recruitment is central to inflammation, involving cell adhesion and migration.
- Intravital microscopy has elucidated general mechanisms of leukocyte recruitment.
- Understanding organ-specific differences, especially in the brain, remains crucial.
Purpose of the Study:
- To review the established paradigm of leukocyte recruitment.
- To highlight knowledge gaps in brain leukocyte recruitment.
- To discuss mechanisms terminating inflammatory responses.
Main Methods:
- Review of existing literature using intravital microscopy.
- Analysis of selectin and integrin roles in leukocyte adhesion.
- Discussion of inflammatory pathway regulation, focusing on Nf kappaB.
Main Results:
- General models of leukocyte rolling and adhesion are well-defined.
- Significant gaps exist in understanding leukocyte recruitment into the brain.
- Nuclear factor Nf kappaB, IL10, IL13, and SLPI influence inflammatory response termination.
Conclusions:
- Leukocyte recruitment is a complex, multi-step process.
- Brain-specific leukocyte recruitment mechanisms require further investigation.
- Modulation of Nf kappaB signaling offers therapeutic targets for controlling inflammation.