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Related Experiment Videos

Apoptosis in leukoaraiosis.

W R Brown1, D M Moody, C R Thore

  • 1Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

AJNR. American Journal of Neuroradiology
|February 11, 2000
PubMed
Summary

Leukoaraiosis involves increased cell death, primarily oligodendrocytes, suggesting apoptosis plays a key role in its development. Chronic ischemia and thickened blood vessels may also contribute to this white matter disease.

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Area of Science:

  • Neuropathology
  • Neurobiology

Background:

  • Leukoaraiosis is a common finding in aging brains, characterized by white matter changes.
  • The underlying mechanisms of leukoaraiosis pathogenesis remain incompletely understood.

Observation:

  • This study investigated apoptosis in a case of leukoaraiosis.
  • Analysis focused on cell DNA fragmentation in affected white matter compared to adjacent areas.

Findings:

  • A significant increase in DNA fragmentation was observed in the leukoaraiosis area.
  • Cells undergoing apoptosis were 2.5 times higher in leukoaraiotic areas than adjacent white matter (P = .004) and 25 times higher than in the cortex (P < .001).
  • Apoptosis, particularly of oligodendrocytes, was implicated in leukoaraiosis pathogenesis.

Implications:

  • Oligodendrocyte apoptosis is a key factor in leukoaraiosis.
  • Partially occluded small veins with collagenous thickening were noted, suggesting chronic ischemia may contribute to or result from leukoaraiosis.

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