Related Experiment Video
Updated: Oct 17, 2026

Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria
Published on: December 14, 2016
Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium
P Seiler1, P Aichele, B Raupach
1Max-Planck-Institut für Infektionsbiologie, D-10117 Berlin, Germany. seiler@mpiib-berlin.mpg.de
Abstract:
Being one of the first cells to invade the site of infection, neutrophils play an important role in the control of various bacterial and viral infections. In the present work, the contribution of neutrophils to the control of infection with different intracellular bacteria was investigated. Mice were treated with the neutrophil-depleting monoclonal antibody RB6-8C5, and the time course of infection in treated and untreated mice was compared by using intracellular bacterial species and strains varying in virulence and replication rate. The results indicate that neutrophils are crucial for the control of fast-replicating intracellular bacteria, whereas early neutrophil effector mechanisms are dispensable for the control of the slow-replicating Mycobacterium tuberculosis.
More Related Videos
Related Concept Videos
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Tuberculosis
Intracellular Movement of Viruses and Bacteria
Colonisation of Pathogens

