Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cellular commitment to radiation-induced apoptosis.

¹Department of Cancer Biology, Lerner Research Institute, and Department of Radiation Oncology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Radiation Research

|February 11, 2000

Summary

Programmed cell death (apoptosis) mechanisms are conserved across species. Research reviewed molecular pathways of radiation-induced apoptosis, crucial for understanding cell death after radiation exposure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction to: MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.

Cell death & disease·2024

Same author

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.

Cell death & disease·2015

Same author

Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.

Cell death & disease·2014

Same author

BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.

Cell death & disease·2013

Same author

Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.

Cell death & disease·2012

Same author

E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma.

Oncogene·2006

Area of Science:

Cell Biology
Molecular Biology
Radiation Biology

Background:

Programmed cell death, or apoptosis, is a fundamental biological process conserved from nematodes to humans.
The molecular machinery for apoptosis is present in all mammalian cells.
Understanding apoptosis is critical for various fields, including medicine and biology.

Framework:

The workshop focused on the commitment phase of radiation-induced apoptosis.
Key molecular mechanisms underlying apoptosis after ionizing radiation exposure were discussed.
The review encompassed recent advancements in understanding these fundamental processes.

Implementation:

Information was presented at the 11th International Congress of Radiation Research.
The focus was on apoptosis triggered by ionizing radiation and other agents.
The review synthesized current knowledge on the molecular basis of this cellular response.

Implications:

Enhanced understanding of radiation-induced apoptosis can inform cancer therapy strategies.
Knowledge of conserved apoptosis pathways aids in comparative biology and evolutionary studies.
This research is fundamental to understanding cellular responses to damaging agents.

Related Experiment Videos