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Sputum elastase in steady-state bronchiectasis.

K W Tsang1, K Chan, P Ho

  • 1University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. kwttsang@hkucc.hku.hk

Chest
|February 12, 2000
PubMed
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Sputum elastase output in bronchiectasis correlates with sputum volume, disease extent, lung function, and leukocytes. Microbial factors showed no correlation with enzymatic or inflammatory markers, suggesting distinct roles in disease.

Area of Science:

  • Pulmonary Medicine
  • Inflammation Research
  • Microbiology

Background:

  • Bronchiectasis is a chronic lung disease characterized by irreversible airway dilation.
  • Understanding the interplay of inflammatory, enzymatic, and microbial factors is crucial for managing bronchiectasis.

Purpose of the Study:

  • To investigate the relationship between sputum elastase levels and clinical, inflammatory, and microbial factors in patients with stable bronchiectasis.
  • To explore the potential independent roles of different components in bronchiectasis pathogenesis.

Main Methods:

  • Prospective study of 30 outpatients with steady-state bronchiectasis.
  • Assessment of 24-hour sputum elastase, bacteria, leukocytes, and inflammatory markers (IL-1beta, IL-8, TNF-alpha, LTB4).
  • Correlations with clinical variables including sputum volume, spirometry (FEV1, FVC), affected lung lobes, and exacerbation history.

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Main Results:

  • Sputum elastase output positively correlated with 24-hour sputum volume and the number of bronchiectatic lung lobes.
  • Elastase output showed a negative correlation with percent predicted FEV1 and FVC, and a positive correlation with leukocyte output.
  • No significant correlation was found between sputum bacteria output and inflammatory or enzymatic factors.

Conclusions:

  • Elastase plays a significant role in bronchiectasis, associated with disease severity and inflammation.
  • Enzymatic, inflammatory, and microbial components may have independent roles in bronchiectasis pathogenesis.
  • Further research into targeted therapies for each component is warranted.