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Genetic restrictions in olive pollen allergy
B Cardaba1, I Cortegano, F Florido
1Immunology Department, Fundacion Jimenez Diaz, Madrid, Spain.
The Journal of Allergy and Clinical Immunology
|February 12, 2000
Summary
Genetic factors influence allergic responses to olive pollen. HLA-DQB1*0201 is associated with IgE and IgG antibodies to Ole e 1 and IgE to Ole e 3, while FcepsilonRI-beta also links to Ole e 1 responses.
Area of Science:
- Immunogenetics
- Allergy Research
- Molecular Biology
Background:
- Olive tree pollen allergen Ole e 1 elicits IgE responses.
- These responses are genetically restricted, particularly by HLA-DQ2.
Purpose of the Study:
- To investigate genetic associations with IgE and IgG antibody responses to Ole e 1.
- To analyze genetic links to IgE responses against the antigen Ole e 3.
Main Methods:
- Studied 22 olive pollen-allergic families (88 individuals).
- Analyzed polymorphisms in HLA-DRB1, HLA-DQB1, TCR-Valpha 8.1, FcepsilonRI-beta, and TNF-beta.
- Used PCR and multiallelic transmission disequilibrium test for genetic association analysis.
Main Results:
- HLA-DQB1*0201 associated with high IgE/IgG to Ole e 1 and IgE to Ole e 3.
- DRB1*0701 linked to high total IgE and IgG to Ole e 1.
- FcepsilonRI-beta polymorphisms associated with IgE/IgG responses to Ole e 1 and olive pollen extract.
Conclusions:
- Confirmed DQB1*0201 association with Ole e 1-specific IgE/IgG.
- Identified a novel association between DQB1*0201 and IgE response to Ole e 3.
- Demonstrated association between FcepsilonRI-beta and IgE responses to Ole e 1.
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