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p53 over-expression and its correlation with PCNA index in nasal polyps
A Lavezzi1, M Mantovani, A Cazzullo
1Institute of Pathology, University of Milan, Italy.
Rhinology
|February 12, 2000
Summary
Nasal polyps (Nps) show higher cell proliferation and p53 oncoprotein over-expression, suggesting tumor-like behavior in many cases. This indicates potential new avenues for understanding nasal polyp pathogenesis.
Area of Science:
- Oncology
- Pathology
- Rhinology
Background:
- The etiopathogenesis of nasal polyps (Nps) remains incompletely understood.
- Investigating cellular markers can elucidate the biological nature of Nps.
Purpose of the Study:
- To define biological features of nasal polyps.
- To investigate p53 over-expression and proliferating cell nuclear antigen (PCNA) in Nps.
Main Methods:
- Immunohistochemistry was used to analyze 32 Np cases and 11 normal mucosa controls.
- PCNA indices and p53 oncoprotein expression were evaluated.
Main Results:
- PCNA indices in Nps (mean 6.8%) were significantly higher than in normal mucosa (mean 2.9%).
- p53 oncoprotein over-expression was observed in 50% of Nps.
- p53 over-expression correlated with high PCNA indices (> 6.8%).
Conclusions:
- Nasal polyps exhibit elevated cell proliferation and p53 oncoprotein expression.
- These findings suggest that Nps may exhibit tumor-like behavior in a significant percentage of cases.