Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function in sarcoidosis.

C B Carrington

    Annals of the New York Academy of Sciences
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Interstitial cellular infiltration in lung biopsies best correlates with impaired lung function in sarcoidosis and related diseases. Histology is crucial for diagnosing allergic alveolitis, distinct from sarcoidosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Organizing interstitial pneumonia: definition of the lesion and attempts to devise an experimental model. 1968.

    The Yale journal of biology and medicine·2002
    Same author

    Observations on the vascularization of secondary pulmonary neoplasms 1974.

    Investigative radiology·1990
    Same author

    Bronchiolitis obliterans.

    Radiology·1986
    Same author

    Follicular bronchitis/bronchiolitis.

    Human pathology·1985
    Same author

    Thoracic surgical problems in asbestos-related disorders.

    The Annals of thoracic surgery·1985
    Same author

    Lung biopsy in rheumatoid arthritis.

    The American review of respiratory disease·1985
    Same journal

    Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

    Annals of the New York Academy of Sciences·2026
    Same journal

    Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

    Annals of the New York Academy of Sciences·2026
    Same journal

    Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

    Annals of the New York Academy of Sciences·2026
    Same journal

    LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

    Annals of the New York Academy of Sciences·2026
    Same journal

    Polyrhythm Perception and Production: A Scoping Review.

    Annals of the New York Academy of Sciences·2026
    Same journal

    DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

    Annals of the New York Academy of Sciences·2026
    See all related articles

    Area of Science:

    • Pulmonary Medicine
    • Pathology
    • Occupational Lung Diseases

    Background:

    • Sarcoidosis, berylliosis, and hypersensitivity pneumonitis share overlapping clinical and histological features.
    • Accurate diagnosis is essential for appropriate patient management and prognosis.

    Purpose of the Study:

    • To compare clinical, roentgenographic, and histological findings in patients with sarcoidosis, berylliosis, and biological dust sensitivity.
    • To identify histological features that best correlate with functional lung impairment and clinical severity.

    Main Methods:

    • Review of clinical, roentgenographic, and histological data from 63 patients.
    • Correlation analysis between histological features, pulmonary function tests, and clinical severity indices.

    Related Experiment Videos

    Main Results:

    • Interstitial cellular infiltration showed the strongest correlation with abnormal lung function, including arterial oxygen pressure and diffusing capacity.
    • Histological findings correlated significantly with clinical severity.
    • Radiographic changes poorly correlated with physiological and pathological features, except in severe cases.
    • Four cases of hypersensitivity pneumonitis (allergic alveolitis) were identified, highlighting the need to review sarcoidosis diagnoses based solely on granulomas.
    • Histological overlap between berylliosis and sarcoidosis was significant, though berylliosis patients had worse mean values and poorer treatment outcomes.

    Conclusions:

    • Interstitial cellular infiltration is a key histological marker for functional impairment in granulomatous lung diseases.
    • Histological review is critical to differentiate hypersensitivity pneumonitis from sarcoidosis, especially in atypical presentations.
    • Berylliosis presents similarly to sarcoidosis but with poorer prognosis and treatment response.