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Identification of Toxic 2,4-Decadienal in Oxidized, Low-Density Lipoprotein by Solid-Phase Microextraction
1Lehrstuhl für Organische Chemie I Universität Bayreuth Universitätsstrasse 30, 95440 Bayreuth (Germany).
Angewandte Chemie (International Ed. in English)
|February 12, 2000
Abstract:
The oxidation of low-density lipoprotein (LDL) in vitro was studied by a combination of solid-phase microextraction and GC/MS. 2-trans,4-cis-2,4-Decadienal, which is strongly toxic in vitro, was detected as the early oxidation product. This compound is degraded further to hexanal and (by cyclization of 4-hydroxy-2-nonenal) to 2-pentylfuran.