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Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good
1UMR CNRS 6521, Université de Bretagne Occidentale Département de Chimie 6, avenue Le Gorgeu, BP 809, 29285 Brest Cedex (France).
Angewandte Chemie (International Ed. in English)
|February 12, 2000
Abstract:
Replacing the ammonium polar head in cationic lipids 1 (A=N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.