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Updated: Jul 24, 2026

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
An outbreak of Streptococcus pneumoniae serotype 1 in a closed community in southern Israel
R Dagan1, S Gradstein, I Belmaker
1Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva 84101, Israel. rdagan@bgumail.bgu.ac.il
Abstract:
An outbreak of Streptococcus pneumoniae serotype 1 occurred in a closed community that was characterized by poverty and crowding. Vaccine was administered to individuals aged >2 years; no new cases occurred among vaccine recipients. Six weeks after vaccination, carriage of serotype 1, but not of other serotypes, decreased 8.8-fold. This suggests that the reduction in serotype 1 carriage reflects the natural course of the outbreak rather than a vaccine effect. Polysaccharide vaccine may be helpful in terminating pneumococcal outbreaks but may not affect pneumococcal carriage.
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