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Altered cAMP-dependent protein kinase A in platelets of patients with obsessive-compulsive disorder
J Perez1, D Tardito, L Ravizza
1Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy. perez.jorge@hsr.it
Objective:
The purpose of this study was to assess cAMP-dependent protein kinase A in patients with obsessive-compulsive disorder (OCD).
Method:
The levels and the activity of protein kinase A were evaluated in whole platelets obtained from 12 unmedicated patients with OCD and 15 healthy comparison subjects.
Results:
The immunolabeling of protein kinase A regulatory subunits type I and II were significantly greater but that of the catalytic subunit significantly lower in patients with OCD than in healthy subjects. The cAMP-stimulated activity in patients with OCD was significantly lower than that in healthy subjects.
Conclusions:
These data suggest a possible role of protein kinase A in the pathophysiology of OCD.