Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Xenotransplantation.

B Soin1, C M Vial, P J Friend

  • 1Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

The British Journal of Surgery
|February 15, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caught in the crossfire: hepato-bilio-pancreatic cancer surgery in the midst of COVID-19.

The British journal of surgery·2020
Same author

Global Transplantation COVID Report March 2020.

Transplantation·2020
Same author

The rise and potential fall of pancreas transplantation.

British medical bulletin·2017
Same author

Significance of steatosis in pancreatic transplantation.

Transplantation reviews (Orlando, Fla.)·2017
Same author

The use of kinase inhibitors in solid organ transplantation.

Transplantation reviews (Orlando, Fla.)·2017
Same author

A Christmas renaissance.

BMJ (Clinical research ed.)·2016
Same journal

Trimester-Specific Safety of Laparoscopic versus Open Abdominal Surgery During Pregnancy: A Systematic Review and Meta-analysis.

The British journal of surgery·2026
Same journal

The Gut Microbiome in Surgical Oncology: Mechanisms, Perioperative Outcomes, and Therapeutic Opportunities.

The British journal of surgery·2026
Same journal

Patient-led, home-based follow-up for colorectal cancer: the DISTANCE multicentre stepped-wedge cluster-randomised trial.

The British journal of surgery·2026
Same journal

Correction to: Reduced secretory efficiency in parathyroid carcinoma: diagnostic value of the PTH-to-tumour-volume ratio.

The British journal of surgery·2026
Same journal

Global disparities in hepatocellular carcinoma outcomes: multicentre study.

The British journal of surgery·2026
Same journal

Surgical Outcomes from Nationwide Implementation of the International Best-Practice for Locally Advanced Pancreatic Cancer (PREOPANC-4) study.

The British journal of surgery·2026
See all related articles

Xenotransplantation offers a potential solution to organ shortages, but overcoming hyperacute rejection remains a challenge. Further research is needed to address antibody-driven rejection and prove the safety of using animal organs for human transplantation.

Area of Science:

  • Medical Science
  • Transplantation Biology
  • Immunology

Background:

  • Clinical transplantation success creates a significant gap between donor organ supply and demand.
  • The urgent need for alternative organ sources drives research into xenotransplantation.
  • Current xenotransplantation strategies are not yet clinically applicable.

Observation:

  • A literature review identified 146 references and 4 personal communications on xenotransplantation.
  • Keywords included hyperacute, acute vascular, and antibody-driven xenograft rejection.
  • Information on preliminary work was included from authors' research.

Findings:

  • Understanding xenograft rejection pathogenesis is advancing rapidly.
  • Strategies effectively abrogate hyperacute rejection.

Related Experiment Videos

  • Controlling antibody-driven acute vascular rejection remains an unmet challenge.

    • Implications:

    • Xenotransplantation holds promise for addressing organ scarcity.
    • Further research is critical to overcome rejection barriers.
    • The safety and viability of xenotransplantation require extensive validation.