Related Experiment Video
Updated: Aug 14, 2026

Using Retinal Imaging to Study Dementia
Published on: November 7, 2017
Morphological alterations of the choroid plexus in late-onset Alzheimer's disease
J M Serot1, M C Béné, B Foliguet
1Laboratoire d'Immunologie (GRIP, JE DRED 251) Faculté de Médecine, UHP Nancy I, France.
Abstract:
Anomalies of the cerebrospinal fluid flow rate and composition that have been reported in patients suffering from Alzheimer's disease (AD) could be related to alterations of the choroid plexuses (CD). Here we report a photonic and electron morphometric study in which we compared the height of CP epithelial cells and the thickness of their basement membrane on post-mortem samples from AD patients, age-matched controls and two newborns. Ageing appeared associated with epithelial atrophy and basement membrane thickening, but these features were significantly accentuated in AD. These data suggest that a dramatic alteration of the secretion and filtration could be involved in the multiparametric pathogenesis of late-onset AD.
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction

