Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Xylitol binding in human dental plaque.

K K Mäkinen, M Rekola

    Journal of Dental Research
    |September 1, 1976
    PubMed
    Summary

    Human dental plaque and saliva bind sugars like sucrose and glucose. Xylitol binding was minimal, suggesting limited plaque microorganism recognition of this sugar alcohol.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Formation of bradykinin from kallidin-10 by aminopeptidase B.

    Nature·2010
    Same author

    An end to crossover designs for studies on the effect of sugar substitutes on caries?

    Caries research·2009
    Same author

    Similarity of the effects of erythritol and xylitol on some risk factors of dental caries.

    Caries research·2005
    Same author

    Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci.

    Caries research·2001
    Same author

    The rocky road of xylitol to its clinical application.

    Journal of dental research·2000
    Same author

    Can the pentitol-hexitol theory explain the clinical observations made with xylitol?

    Medical hypotheses·2000

    Area of Science:

    • Oral microbiology
    • Biochemistry

    Background:

    • Dental plaque and saliva are key in oral health.
    • Understanding microbial interactions with carbohydrates is crucial for preventing dental caries.

    Purpose of the Study:

    • To investigate the binding affinities of human dental plaque and whole saliva sediment for various carbohydrates.
    • To determine the extent to which plaque microorganisms recognize and bind xylitol.

    Main Methods:

    • Radiolabeled (14C) sucrose, fructose, glucose, sorbitol, and xylitol were used.
    • Binding assays were performed on human dental plaque and whole saliva sediment.
    • Plaque samples were subjected to a five-second ultrasonic shock to assess binding strength.

    Main Results:

    • Sucrose, glucose, sorbitol, and fructose exhibited significant binding to both plaque and saliva sediment, in decreasing order of affinity.
    • Binding was most pronounced in plaque treated with ultrasonic shock.
    • Xylitol demonstrated only insignificant binding, indicating limited specific recognition by plaque microorganisms.

    Conclusions:

    • Human dental plaque and saliva sediment show differential binding of common dietary sugars.
    • The minimal binding of xylitol suggests a restricted capacity for plaque microorganisms to recognize this sugar alcohol.
    • These findings have implications for understanding carbohydrate metabolism in dental plaque and the cariostatic potential of xylitol.

    Related Experiment Videos