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Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety
1Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
Bioorganic & Medicinal Chemistry Letters
|February 15, 2000
Abstract:
The synthesis and biological activity of a series of new 1beta-methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-I comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-I, respectively.