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DMBA and immunosuppression in the Syrian golden hamster
Journal of Dental Research
|October 1, 1976
Abstract:
The immunosuppressive effects of topically applied 9, 10 dimethyl 1, 2 benzanthracene (DMBA) were investigated in the Syrian Golden hamster. Tri-weekly doses of DMBA were administered, with some hamsters receiving both DMBA and X-radiation. DMBA and DMBA-plus-radiation groups demonstrated decreased immune responsiveness relative to their control counterparts. Potential immunosuppressive effects of carcinogen and carcinoma are discussed.