Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed type hypersensitivity: current theories with an historic perspective.

C A Black1

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences Magee-Womens Research Institute Pittsburgh, USA.

Dermatology Online Journal
|February 16, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elucidating the Mechanism(s) Underlying Antipsychotic and Antidepressant-Mediated Fractures.

Journal of mental health & clinical psychology·2019
Same author

Evaluation of gene modification strategies for the development of low-alcohol-wine yeasts.

Applied and environmental microbiology·2012
Same author

In defense of discrepant analysis.

Journal of clinical epidemiology·2001
Same author

Vaginal mucosa serves as an inductive site for tolerance.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same author

Increased severity of Candida vaginitis in BALB/c nu/nu mice versus the parent strain is not abrogated by adoptive transfer of T cell enriched lymphocytes.

Journal of reproductive immunology·2000
Same author

Major histocompatibility haplotype does not impact the course of experimentally induced murine vaginal candidiasis.

Laboratory animal science·2000

Delayed type hypersensitivity (DTH) is a cell-mediated immune response dependent on memory T cells. Contemporary research debates the roles of Th1 and Th2 cells in DTH reactions, challenging earlier theories.

Area of Science:

  • Immunology
  • Cellular immunology

Background:

  • Delayed type hypersensitivity (DTH) reactions, discovered in 1882, were initially debated regarding their immune mediation.
  • Landsteiner and Chase confirmed DTH is cell-mediated, not humoral, in the 1940s.

Observation:

  • DTH skin tests involve injecting antigens, eliciting induration, swelling, and monocytic infiltration within 24-72 hours.
  • The reaction is critically dependent on memory T cells, with both CD4+ and CD8+ subsets modulating the response.

Findings:

  • The role of Th1 and Th2 cells in DTH is a contemporary focus of debate.
  • Initially, Th1 cells were considered inducers (via IFN-γ) and Th2 cells downregulators.
  • Emerging evidence suggests Th2 cells may also participate in certain inflammatory cell-mediated immune responses.

Related Experiment Videos

Implications:

  • Understanding DTH mechanisms is crucial for diagnosing past antigen exposure.
  • Clarifying T-cell subset roles in DTH can inform therapeutic strategies for immune-mediated diseases.
  • This review synthesizes evidence on DTH variations and T-cell involvement in cell-mediated immunity.