Features of unusual metastases from prostate cancer

A retrospective study of CT examinations on 508 patients with prostate carcinoma was performed in order to document the presence or absence of uncommon nodal and extranodal metastases according to pre-defined criteria. 45 atypical metastases were demonstrated in 36 patients. There were 23 atypical nodal metastases including unusual distribution (19/23), large volume (7/23) and atypical morphology or contrast enhancement pattern (8/23). 22 atypical extranodal metastases included orbit/skull base (11), pulmonary (4), liver (3), intracranial (2), ocular (1) and adrenal (1). Atypical prostate carcinoma metastases are usually encountered in the presence of known advanced disease but can be the presenting feature of malignancy or the only sign of distant spread. Knowledge of atypical manifestations of metastatic disease will reduce diagnostic delay, allow accurate staging and lead to the effective and timely delivery of appropriate treatment.