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Novel translocation t(3;11)(p21;q24) in multiple myeloma characterised by FISH
A Smith1, R de Lambert, L Robson
1Department of Cytogenetics, Royal Alexandra Hospital for Children, Westmead, Australia.
Annales De Genetique
|February 16, 2000
Abstract:
We present a 72 year old man with multiple myeloma (MM). Cytogenetic and FISH analysis of bone marrow aspirate showed a novel translocation -der(11)t(3;11)(p21;q24). The unbalanced karyotype led to substantial partial trisomy for chromosome 3p and small partial monosomy 11q. Structural rearrangements of chromosome 3 are uncommon in MM and these are reviewed. The patient died 2 years after the diagnosis of MM was made.