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Related Experiment Videos

Epidural meperidine does not cause hemodynamic changes in the term parturient.

K S Khaw1, W D Ngan Kee, L A Critchley

  • 1Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Peoples Republic of China. kimkhaw@cuhk.edu.hk

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|February 16, 2000
PubMed
Summary

Epidural meperidine (50 mg) caused minimal hemodynamic changes in parturients undergoing Cesarean section. This analgesic dose demonstrated a slight increase in cardiac output and mean arterial pressure.

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Area of Science:

  • Anesthesiology and Pain Management
  • Obstetric Anesthesia

Background:

  • Meperidine possesses local anesthetic properties, potentially influencing hemodynamic stability when administered epidurally.
  • Epidural anesthesia is commonly used for Cesarean sections, necessitating an understanding of drug-induced hemodynamic effects.

Purpose of the Study:

  • To evaluate the hemodynamic effects of a 50 mg analgesic dose of epidural meperidine in term parturients undergoing elective Cesarean section.
  • To assess changes in mean arterial pressure, cardiac output, and heart rate following epidural meperidine administration.

Main Methods:

  • 34 ASA 1-2 term parturients scheduled for Cesarean section received epidural anesthesia.
  • Hemodynamic parameters were measured using oscillotonometry and electrical bioimpedance before and after epidural saline and 50 mg meperidine injections.

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  • Sensory blockade was assessed using loss of temperature discrimination.

    • Main Results:

    • Epidural meperidine resulted in a statistically significant but small increase in cardiac output (5.81 to 6.04 L/min) and mean arterial pressure (77.1 to 79.3 mm Hg).
    • A sensory blockade level ranging from L1 to T1 was achieved in 94% of patients after epidural meperidine.
    • Epidural saline administration did not produce significant hemodynamic changes.

    Conclusions:

    • A 50 mg dose of epidural meperidine causes minimal hemodynamic alterations in term parturients.
    • Epidural meperidine can be considered for analgesia in Cesarean sections with careful hemodynamic monitoring.