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Pathogenesis of and immunity to melioidosis

P J Brett1, D E Woods

  • 1Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Alta, Canada.

Acta Tropica
|February 16, 2000
PubMed

Insights

No vaccine currently exists for melioidosis, a disease caused by Burkholderia pseudomallei. Research identifies flagellin and O-polysaccharide antigens as promising candidates for a new vaccine.

Area of Science:

  • Bacteriology
  • Immunology
  • Vaccinology

Background:

  • Melioidosis, caused by Burkholderia pseudomallei, is a significant health concern in endemic areas.
  • There is currently no licensed vaccine available for melioidosis prevention.

Purpose of the Study:

  • To identify and characterize B. pseudomallei antigens for vaccine development.
  • To develop a vaccine construct for active immunization against melioidosis.

Main Methods:

  • Biochemical approaches
  • Immunological approaches
  • Molecular approaches

Main Results:

  • Flagellin proteins are identified as promising vaccine candidates.
  • O-polysaccharide (PS) antigens are identified as promising vaccine candidates.

Conclusions:

  • Flagellin and O-polysaccharide antigens show potential for a melioidosis vaccine.
  • Further research is warranted to develop an effective vaccine against B. pseudomallei.

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