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Chromogranin A expression in hepatocellular carcinoma in a patient with germline MEN1 gene mutation
K Nakajima1, A Sakurai, M Katai
1Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto.
Internal Medicine (Tokyo, Japan)
|February 16, 2000
Abstract:
Hepatocellular carcinoma (HCC) was found in a patient with multiple endocrine neoplasia type 1 (MEN 1). The intriguing finding was that the HCC in the patient was positively stained for chromogranin A (CgA), a cellular marker for endocrine and neuroendocrine tumors. The patient had a pancreas endocrine tumor and type C hepatitis, that made pathological diagnosis of the origin of the tumor complicated.