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Cytoprotection and intracellular calcium
1Laboratory of Clinical Pharmacology, Dept. of Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Journal of Physiology, Paris
|February 16, 2000
Abstract:
It seems that prostacyclin has an increasing effect on gastric mucosal (antral and fundic) calmodulin level in rats. Using either the calcium channel blocker verapamil or anti-calmodulin drugs (diazepam, trifluoperazine,) the cytoprotective effect of prostacyclin can be inhibited. Therefore, it is probable that calcium ions and calcium-activated calmodulin play a role in the effect of prostacyclin.