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Related Experiment Videos

The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.

H Yamagishi1, E N Olson, D Srivastava

  • 1Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.

The Journal of Clinical Investigation
|February 17, 2000
PubMed
Summary
This summary is machine-generated.

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The transcription factor dHAND is crucial for embryonic vascular development and angiogenesis. Its absence in mice leads to severe vascular defects, impacting smooth muscle cell differentiation and potentially VEGF signaling.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Cardiovascular research

Background:

  • Vascular development relies on intricate interactions between endothelial and mesenchymal cells.
  • The transcription factor dHAND/Hand2 plays a role in the developing vascular system.

Purpose of the Study:

  • To investigate the role of dHAND/Hand2 in embryonic vascular development and angiogenesis.
  • To identify downstream targets of dHAND/Hand2 in vascular development.

Main Methods:

  • Targeted deletion of the dHAND gene in mice.
  • Analysis of embryonic and yolk sac vascular development.
  • Gene expression profiling using subtractive hybridization.

Main Results:

Related Experiment Videos

  • dHAND-deficient mice exhibited severe embryonic and yolk sac vascular defects.
  • Vascular mesenchymal cells failed to differentiate into smooth muscle cells and contact endothelial cells.
  • Neuropilin-1, a VEGF receptor, was downregulated in dHAND-mutant hearts.

    • Conclusions:

    • dHAND is essential for proper embryonic vascular development and angiogenesis.
    • dHAND may regulate angiogenesis through pathways involving VEGF signaling, potentially via neuropilin-1.