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DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion
H Kashiwagi1, H Kijima, S Dowaki
1Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
International Journal of Oncology
|February 17, 2000
Summary
DF3 (MUC 1) glycoprotein is expressed in gallbladder adenocarcinomas, correlating with advanced tumor stage and lymph node metastasis. This suggests DF3 plays a role in gallbladder cancer progression and metastasis.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- DF3 (MUC 1) is a high molecular weight glycoprotein implicated in tumor metastasis.
- DF3's expression patterns in human gallbladder carcinomas remain largely unestablished.
Purpose of the Study:
- To investigate DF3 expression in human gallbladder adenocarcinoma.
- To determine the clinicopathological significance of DF3 expression in gallbladder cancer.
Main Methods:
- Immunohistochemical analysis of DF3 expression in cancer cells and stroma.
- Correlation of DF3 expression with TNM classification and lymph node metastasis.
Main Results:
- DF3 immunoreactivity was observed in both cancer cells (cytoplasmic type, 50.0%) and stroma (stromal type, 46.3%).
- Cytoplasmic and stromal DF3 expression significantly correlated with advanced tumor stages (T2-4 vs. T1) (p<0.001).
- Lymph node metastasis was frequent in patients with cytoplasmic and stromal DF3-positive tumors (59.3% and 60.0%, respectively).
Conclusions:
- DF3 expression is prevalent in human gallbladder adenocarcinomas.
- DF3 expression is significantly associated with tumor progression and metastasis in gallbladder cancer.
- DF3 may serve as a potential biomarker for gallbladder cancer advancement.