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Updated: Oct 17, 2026

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review)

B Aunoble1, R Sanches, E Didier

  • 1Laboratoire d'Oncologie Moleculaire, INSERM CRI 9502/EA 2145, Centre Jean Perrin, BP 392, 63011 Clermont-Ferrand, France.

International Journal of Oncology
|February 17, 2000
PubMed

Insights

Ovarian cancer, a leading cause of gynecologic death, involves genetic alterations in oncogenes and tumor suppressor genes. Key genes like HER-2/neu, c-myc, K-ras, p53, BRCA1, and BRCA2 are implicated in its development and prognosis.

Area of Science:

  • Gynecologic Oncology
  • Cancer Genetics
  • Molecular Biology

Background:

  • Ovarian cancer is a leading cause of cancer-related death in Western countries.
  • Carcinogenesis involves genetic alterations in oncogenes and tumor suppressor genes crucial for cell growth regulation.
  • Sporadic and hereditary ovarian cancers involve distinct genetic mutations.

Purpose of the Study:

  • To review the function of key genes involved in ovarian cancer.
  • To examine the incidence of gene mutations in ovarian carcinogenesis.
  • To assess the prognostic value of these genetic alterations in ovarian cancer.

Main Methods:

  • Literature review of genetic alterations in ovarian cancer.
  • Analysis of gene mutations in sporadic and hereditary ovarian cancer.
  • Evaluation of protein function and prognostic significance.

Main Results:

  • Frequent mutations/overexpression of HER-2/neu, c-myc, K-ras, and p53 in sporadic ovarian cancer.
  • BRCA1 and BRCA2 are frequently involved in high-risk hereditary ovarian cancer.
  • These genetic alterations play roles in carcinogenesis and prognosis.

Conclusions:

  • Genetic alterations in specific oncogenes and tumor suppressor genes are critical in ovarian cancer development.
  • BRCA1 and BRCA2 are significant in hereditary ovarian cancer.
  • Understanding these genetic factors is vital for prognosis and potential therapeutic strategies.

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