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Kinetics of base catalyzed racemization of ibuprofen enantiomers
X Yuchun1, L Huizhou, C Jiayong
1Institute of Chemical Metallurgy, Chinese Academy of Sciences, 100080, Beijing, People's Republic of China. yexie@263.net
International Journal of Pharmaceutics
|February 17, 2000
Abstract:
The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization, under different base and substrate concentrations, is established and experimentally verified.